Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction

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Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.

To determine if doxapram stimulates the carotid body through the same mechanism as hypoxia, we compared the effects of doxapram and hypoxia on isolated-perfused carotid bodies in rabbits. Doxapram stimulated the carotid body in a dose-dependent manner. In Ca(2+)-free solution, neither doxapram nor hypoxia stimulated the carotid body. Although, doxapram had an additive effect on the carotid body...

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Further cholinergic aspects of carotid body chemotransduction of hypoxia in cats.

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ژورنال

عنوان ژورنال: Respiratory Physiology & Neurobiology

سال: 2005

ISSN: 1569-9048

DOI: 10.1016/j.resp.2005.01.005